Diffusion, Crowding & Protein Stability in a Dynamic Molecular Model of the Bacterial Cytoplasm
Figure 3
Translational and rotational diffusion in the cytoplasm model.
A. Dtrans values for the three most abundant proteins plotted versus observation interval δt; error bars indicate the standard deviation of values obtained from three independent simulations; solid lines represent fits to the data obtained by integrating the analytical functions shown in the next panel. B. Computed anomality exponents, α, obtained by numerically differentiating the Dtrans values shown in A; solid lines represent fits to the data using an analytical function defined in Methods. C. Anomality exponent, α, computed at the shortest accessible time interval (δtmid = 144ps) plotted for all molecule types versus molecular weight; error bars represent standard deviations from the three independent BD simulations. D. Long-time Dtrans values expressed relative to infinite-dilution values plotted versus molecular weight of each molecule type; asterisk denotes GFP. E. Short-time Drot values expressed relative to infinite-dilution values plotted versus molecular weight of each molecule type. F. Ratio of the effective translational and effective rotational viscosities, plotted for all molecule types versus molecule weight.