Temporal Sensitivity of Protein Kinase A Activation in Late-Phase Long Term Potentiation
Figure 4
Simulations were repeated with the dopamine receptor blocked, to evaluate the contribution of dopamine to L-LTP.
Cumulative PKA activity is reduced significantly with both massed and spaced stimulation intervals. The PKA activity with spaced stimulation and dopamine blocked is comparable to PKA activity with massed stimulation and dopamine unblocked. The reduction in PKA activity for the massed stimulation case is not functionally significant because PKA is not needed for L-LTP produced by massed stimulation.