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Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells

Figure 5

Characterization of protrusion/adhesion phenotypes through stochastic simulations.

The model system was allowed to evolve stochastically, with all species numbers equal to zero initially. a. Protrusion velocity v is plotted as a function of time for = 0.3 min⁻¹, N^* = 3, and a matrix of E_s and I_n values as indicated. b. The same (E_s, I_n) matrix was repeated for different values of and N^* as indicated, and each simulation was coded according to the apparent phenotype. The matrix framed with a thicker border corresponds to the simulations shown in a. The raw data for each of these simulations, v(t) and s(t), are provided in Supplementary Figs. S1 and S2, respectively.

doi: https://doi.org/10.1371/journal.pcbi.1000688.g005