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Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells

Figure 4

Regions of model bistability.

In each plot, the shaded region of (, E_s) parameter space indicates where there are multiple fixed points ( values given in units of min⁻¹). Outside of these regions, the model is monostable, supporting either low (low or high E_s) or high (high or low E_s) protrusion. The values of C_s and I_n are varied as indicated, and all other parameters are assigned base case values (Supplementary Table S1).

doi: https://doi.org/10.1371/journal.pcbi.1000688.g004