A Dynamic Model of Interactions of Ca2+, Calmodulin, and Catalytic Subunits of Ca2+/Calmodulin-Dependent Protein Kinase II
Figure 5
Model 2: coarse-grained model of binding among Ca2+, CaM and CaMKII.
The reaction network includes only pairs of Ca2+ ions, assuming highly cooperative binding at each CaM terminus. Rate constants were derived from those for Model 1 as described in Text S1.