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A Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity

Figure 10

Synaptic plasticity in the absence of DARPP-32.

(A) Synaptic plasticity due to varying strengths of dopamine input combined with calcium input. (B) Synaptic plasticity due to varying strengths of calcium input without dopamine input. Black lines indicate results from the original model (control), and green lines indicate results from the modified model, where DARPP-32 is fixed at (DARPP-32 knockout condition). (C) Contour plot of synaptic plasticity in the DARPP-32 knockout condition as a function of calcium and dopamine input.

Figure 10

doi: https://doi.org/10.1371/journal.pcbi.1000670.g010