A Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity
Figure 9
Responses of PKA and PP1 in the absence of DARPP-32.
(A–B) Maximal responses of active PKA to various levels of dopamine and calcium input, respectively. (C–D) Maximal responses of active PP1 to various levels of dopamine and calcium input, respectively. For all panels, black lines indicate results from the original model (control), and green lines indicate results from the modified model, where DARPP-32 is fixed at (DARPP-32 knockout condition).