A Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity
Figure 8
The role of the CK1-Cdk5 pathway.
The maximum response of (A) Cdk5 and (B) PP2A activities to different levels of calcium input. (C) Altered transient responses of phosphorylated Thr75 by removing the Ck1-Cdk5 pathway. The solid lines are responses from the original model. Dotted lines are the responses from the modified model, where the CK1-Cdk5 pathway was removed from the original model. Different levels of calcium input are denoted by different colors: red for calcium input; and blue for
calcium input.