A Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity
Figure 6
Dopamine- and calcium-dependent synaptic plasticity reproduced by the model.
(A) Transient time courses of synaptic efficacy induced by (solid line),
(dotted line), and
(dashed line) dopamine input coincident with
calcium input. (B) Transient time courses of synaptic efficacy induced by
(solid line),
(dotted line), and
(dashed line) calcium input without dopamine input. In all cases from (A) and (B), input was initiated at 0 seconds and synaptic efficacy was evaluated by the number of AMPA receptors in the post-synaptic membrane. (C) Synaptic plasticity as a function of dopamine input with
calcium input. The dopamine concentration was fixed at
in the depleted condition, but set to
steady state in the remaining conditions. (D) Synaptic plasticity as a function of calcium input. For (C) and (D), plasticity was evaluated by the ratio of the number of AMPA receptors in the post-synaptic membrane prior to and 10 minutes after stimulation onset.