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A Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity

Figure 5

Transient activation responses of intracellular molecules from the original model.

Line colors denote four different conditions: calcium influx without dopamine input (cyan); calcium influx without dopamine input (blue); calcium influx coincident with dopamine input (magenta); and dopamine input in the absence of calcium influx (red). (A–O) Each plot indicates the activation state of each protein. (P) AMPARp indicates total concentration of phosphorylated AMPA receptor from at least one phosphorylation site.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1000670.g005