A Kinetic Model of Dopamine- and Calcium-Dependent Striatal Synaptic Plasticity
Figure 3
Schematic diagram of the AMPA receptor trafficking model.
AMPA receptors are phosphorylated at Ser845 and Ser831 by PKA and CaMKII, respectively, and are also dephosphorylated by PP1 and PP2A. The phosphorylated AMPA receptors bind to anchor protein (Anchor) and are inserted into the cell membrane. In contrast, dephosphorylated AMPA receptors are removed from the membrane. AMPA receptors released from anchor protein are degraded and stored in cytosol (Bulk AMPAR).