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Explicit Kinetic Heterogeneity: Mathematical Models for Interpretation of Deuterium Labeling of Heterogeneous Cell Populations

Figure 2

Model predictions for exponentially distributed turnover rates.

We have plotted the changes in the fraction of labeled DNA according to the explicit kinetic heterogeneity model with exponentially distributed turnover rates (eqn. (5), mean day). Predicted changes are shown for a short labeling period ( day, solid line) and a long labeling period ( days, dashed line) on a linear (panel A) and a logarithmic (panel B) scale. The initial uplabeling rate is independent of the length of the labeling period and is given by . The initial rate of delabeling, in contrast, depends on the length of the labeling period and is approximately twice as fast in the case of short-term labeling as compared to long-term labeling.

doi: https://doi.org/10.1371/journal.pcbi.1000666.g002