In Silico Analysis of the Apolipoprotein E and the Amyloid β Peptide Interaction: Misfolding Induced by Frustration of the Salt Bridge Network
Figure 4
Proposed model for the Aβ peptide and ApoE4 interaction.
The interaction of Aβ with ApoE4 rearranges the salt bridge network. This is the overall representation of the interaction effect between the peptide and the protein. (Upper panel) 3D plot of the ApoE4-Aβ complex (colored blue and golden respectively) depicting the rearranged salt bridge network (green dotted lines). Selected residues have been represented as ball and sticks and colored by element (C, grey; O, red; N, blue). (Lower panel) 2D scheme for a clearer understanding of the rearranged salt bridge network. The sub index for the ApoE4 residues indicates helix location. Aβ residues into grey shaded boxes are indicated by underlined and italics characters.