Acute Effects of Sex Steroid Hormones on Susceptibility to Cardiac Arrhythmias: A Simulation Study
Figure 8
Simulated drug-induced arrhythmias during short-long-short pacing protocols.
(A) Comparison of 2D heterogeneous tissue dynamics in the absence or presence of E-4031 during the late follicular phase, and application of testosterone 3 nM with E-4031. (B) The same protocol as above was used, but the premature stimulus was applied during the vulnerable window in the middle of endocardial near the boundary between endocardial region and M cells. The late follicular phase with E-4031 is shown.