Quantitative Modeling of GRK-Mediated β2AR Regulation
Figure 4
Simulated effects of varying rates of GRK phosphorylation and arrestin binding.
A–C: Simulated effects of ten-fold variation in GRK phosphorylation rates on (A) phosphorylation, (B) internalization and (C) desensitization. D–E: Simulated effects of ten-fold variation in arrestin binding rates on (D) phosphorylation, (E) internalization and (F) desensitization. Experimental data as given in Figure 2A, C, and Figure 3B.