Associating Genes and Protein Complexes with Disease via Network Propagation
Figure 3
Case studies of inferred complexes.
Examples of inferred protein complexes and their associated diseases. Circular nodes represent proteins and their connecting edges represent protein-protein interactions. Diseases are denoted by square nodes, connected by phenotypic similarity edges. Green dashed edges represent known gene-disease associations; red edges connect a disease to a gene that lies within its associated genomic interval. The complexes were generated for the query diseases (A) Ataxia-Telangiectasia, (B) Hereditary Prostate Cancer type 8 and (C) MOPD-I.