Combining Structure and Sequence Information Allows Automated Prediction of Substrate Specificities within Enzyme Families
Figure 2
View on the superimposed active sites of IPMDH and ICDH.
The first chain of the homo-dimeric enzyme is represented by its solvent-excluded surface. The second chain is depicted in a backbone representation. The two substrates isocitrate (purple) and isopropylmalate (green) lie in the interface of the two chains. IPMDH sidechains are coloured green and sidechains from ICDH (PDB-Id: 1AI2, [40]) are coloured purple. This figure was created using BALLView [41].