Identification of Networks of Co-Occurring, Tumor-Related DNA Copy Number Changes Using a Genome-Wide Scoring Approach
Figure 4
Significance of finding direct interactions in co-occurring genomic loci.
For two scales the top 50 co-occurring gene lists for the gain-gain, loss-loss and loss-gain situations were compared to a random set of 100 pairs of genomic loci. For each genomic pair two gene sets were queried for direct interactions using the STRING database. Significance was ascertained using Fisher's exact test on the ratios between all genes and the interacting genes for the co-occurrence gene sets versus the random gene set.