A Stochastic Model for Microtubule Motors Describes the In Vivo Cytoplasmic Transport of Human Adenovirus
Figure 5
Hexon not protein IX is the predicted to be motor binding site on the adenovirus capsid.
(A) Schematic model of the icosahedral adenovirus capsid with the major capsid protein hexon (blue hexagonal structures representing trimers), and pIX (yellow lines representing trimers). An icosahedral facette is enlarged in (B), where hexon-hexon trimer interfaces are depicted in red and in light green the microtubule orientation that maximizes the overlap with one facet. Note that the fourth trimer of pIX is covered by the red lines depicting hexon-hexon interfaces. (C, D) Directed motion length and velocity distributions for protein IX deficient adenovirus recorded in HeLa cells 30 to 90 min post infection.