The Presence of VEGF Receptors on the Luminal Surface of Endothelial Cells Affects VEGF Distribution and VEGF Signaling
Figure 5
Flows of VEGF disappearing upon ligated receptor internalization as a function of the VEGF secreted.
The setup is similar to that in Figure 4. A. Linear relationship between the VEGF secreted and the VEGF disappearing via internalization of VEGF-bound abluminal receptors. B. Non-linear relationship between the VEGF secreted and the VEGF disappearing via internalization of the luminal receptors it has bound to. Black circles: no abluminal receptors; red circles: 2,500 abluminal receptors/endothelial cell; green triangles: 5,000 abluminal receptors/endothelial cell; yellow triangles: 7,500 abluminal receptors/endothelial cell; blue squares: 10,000 abluminal receptors/endothelial cell.