Bistability of Mitochondrial Respiration Underlies Paradoxical Reactive Oxygen Species Generation Induced by Anoxia
Figure 2
The prediction of bistability in complex III operation.
The levels of semiquinone (A) and free ubiquinol (B) were chosen as the indicators of state of system. If the system is in highly reduced state initially, it remains in this state (thick gray curves); if initially the levels of reduction are lower, the system evolves to another steady state characterized by lower levels of semiquinone and, respectively, ROS production. The same type of curves in (A) and (B) refers to the same simulation.