Human Cancer Protein-Protein Interaction Network: A Structural Perspective
Figure 8
Representation of ERBB3-NRG1 interaction schematically.
The interactions are visualised using VMD [78] A) ERBB3 (1m6b_A) and NRG1 (1hae_A) are shown as newcartoon diagram in blue and red color, respectively. The transparent surface represents the interface region. The labeled residues (represented by their Cα atoms) of 1hae_A are reported to be critical for binding in a previous work [58]; i.e. when they are mutated to alanine, the binding affinity for ERBB3 was significantly reduced. B) HER3 (blue) – pertuzumab heavy chain (yellow) is shown. Pertuzumab shares the same interface with NRG1 (see “An inhibitor affecting Erb signaling pathway: pertuzumab” section).