Trade-off between Positive and Negative Design of Protein Stability: From Lattice Models to Real Proteins
Figure 2
Relationship between the impact of negative design on the stability of different lattice folds and their respective average contact-frequencies.
The values of a measure of the effect of negative design of stability, <D(i,j)>long, for the 1081 different folds of 25 residue-long sequences on a 5×5 lattice are plotted against their respective average contact-frequencies, . A linear correlation is observed with r = 0.6390 and a P-value<0.0001.