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Modeling Latently Infected Cell Activation: Viral and Latent Reservoir Persistence, and Viral Blips in HIV-infected Patients on Potent Therapy
Figure 9
Numerical simulations of the homeostasis model (Eq. (7)) and sensitivity tests of several parameters.
The system is at steady state and at 
drug is applied. A, D, G and J: the latent reservoir size; B, E, H and K: viral load; C, F, I and L: the ratio of 
to 
, i.e., the relative contributions to the latent reservoir persistence from ongoing viral replication and latently infected cell proliferation. A, B and C: the carrying capacity of total latently infected cells is 
. We use different proliferation rates: 
(blue solid), 
(green dash-dotted), and 
(red dashed). The black solid line represents the detection limit. D, E and F: 
is fixed. Different carrying capacities of the total latently infected cells are used: 
(green dashed), 
(blue solid), 
(red dash-dotted). G, H and I: we use different fractions of infections that result in latency: 
(red dashed), 
(blue solid), and 
(black dotted). J, K and L: we use different drug efficacies: 
(red dashed), 
(blue solid), 
(black dotted). 
and the carrying capacity 
are fixed for the last two rows. The other parameter values used are listed in Table 1.
doi: https://doi.org/10.1371/journal.pcbi.1000533.g009