Modeling Latently Infected Cell Activation: Viral and Latent Reservoir Persistence, and Viral Blips in HIV-infected Patients on Potent Therapy
Figure 5
Numerical simulations of Eq. (4) with different duration and frequency of activation.
We fixed the proliferation rate of activated cells to be . Column A:
,
. No statistically significant decay of the latent reservoir is observed. Column B:
,
. The latent reservoir decays at a very slow rate. Column C:
,
. In this realization, there are 8 activations in 300 days. The latent reservoir decays more quickly than in Figure 3C. The other parameter values used are the same as those in Figure 3. The blue horizontal line represents the detection limit of 50 RNA copies/mL.