Modeling Latently Infected Cell Activation: Viral and Latent Reservoir Persistence, and Viral Blips in HIV-infected Patients on Potent Therapy
Figure 2
Schematic representation of the model with latently infected cell activation (Eq. (4)).
Following encounter with cell-specific antigens, latently infected cells are activated and undergo programmed clonal expansion and contraction. A number of activated latently infected cells transition to the productive class and produce virions, whereas another small fraction of activated cells revert back to the latent state, providing a mechanism to replenish the latent reservoir.