Structure-Based Predictive Models for Allosteric Hot Spots
Figure 5
Hotspot predictions mapped to the inactive state structure of myosin II.
Predictions made by the top 9 highest-precision Hybrid Feature Set models according to the voting scheme for myosin II motor domain mapped onto the inactive state structure (1vom). Refer to Figure 4 above for an explanation of the coloring. Residues that met our criteria for classification as hotspot and included in the independent data set are rendered in van der Waals spheres. Switch-II (a region with high homology to the switch region of G-proteins that couples GTP hydrolysis to effector-domain conformation) residues (454–459) are depicted in van der Waals spheres as well, and colored according to the heat map.