The Mechanism of Ubiquitination in the Cullin-RING E3 Ligase Machinery: Conformational Control of Substrate Orientation
Figure 2
Structure superimposition of substrate-binding proteins.
(A) Superposition of Elongin C (purple, violet) and VHL-box/SOCS-box of pVHL (Cyan) (PDB code 1lm8) and SOCS2 (pink) (PDB code 2c9w). The substrate binding domain of pVHL and SOCS2 are different, but their substrate binding sites (blue and red as circled) overlap. (B) Superposition of Skp1 (blue, red, orange or green) and F-box of Skp2 (Cyan) (PDB code 2ast), Fbw7 (pink) (PDB code 2ovq), Cdc4 (yellow) (PDB code 1nex) and Fbs1 (lime) (PDB code 2e31). Their substrate binding sites (blue, red, orange or green) overlap.