Statistical Use of Argonaute Expression and RISC Assembly in microRNA Target Identification
Figure 6
Estimated effects of targeting Ago 2 and Ago 1,3,4 RISC proxies.
X- and y-axes correspond to estimated effects of targeting RISC proxies composed of Ago 2 (β1) and Ago 1, 3 or 4 (β5) on targeted mRNA levels for those cases where the model successfully identifies the known targeting pair and estimates both effects in the minimum AIC submodel. Observed values are inversely related in sign with similar magnitudes of effect strength. This is consistent with the hypothesized interference of observable target cleavage by RISCs composed of Ago 2 by those composed of Ago 1,3 or 4.