Statistical Use of Argonaute Expression and RISC Assembly in microRNA Target Identification
Figure 3
Marginal and system biology-compensated E2F1 and miR-17-5p expression levels.
E2F1 and miR-17-5p expression levels in the Madison data are compared marginally in the top left and after compensation for biological and idiosyncratic covariates on the top right. Analogous results for the OSU data are provided in the bottom row. In either dataset, marginal RNA expression levels are not representative of the known targeting relationship between miR-17-5p and E2F1. After compensation the relationship between these RNAs can be observed.