Statistical Use of Argonaute Expression and RISC Assembly in microRNA Target Identification
Figure 2
Marginal expression level comparisons of known target pairs.
Marginal correlations of m- and miRNA expression levels are typically and inappropriately positive in all datasets under analysis. Further, in the Madison and Broad datasets the amount of variation in targeted mRNA expression captured by that of targeting miRNA is extremely low. In the combined dataset, high R2 values are indicative only of the amount of variation in mRNA expression due to data origin.