A Novel Scoring Approach for Protein Co-Purification Data Reveals High Interaction Specificity
Figure 2
Evaluation of the IDBOS scoring scheme.
Coverage versus accuracy data (see Materials and Methods) comparing the scoring schemes of IDBOS (this work) and Collins et al. [16], when applied to the purification data of Gavin et al. [8]. Four diverse reference interaction data sets were used: (A) BGS; (B) PCA; (C) SBMC2; and (D) MIPS. See Materials and Methods for full descriptions of these references. Also shown is the scored data of Hart et al. [17] (determined by multiplying individual results across the Gavin et al. [8], Krogan et al. [9], and Ho et al. [7] AP/MS data sets) and evaluations for Y2H data sets of Yu et al. [6] (CCSB-YI1), Ito et al. [4] (core subset), Uetz et al. [5], and a union of these data sets [6] (Y2H-union).