Parallel Computational Subunits in Dentate Granule Cells Generate Multiple Place Fields
Figure 4
Changing the resistance influence the isolation of compartments, but not the detection of dendritic spikes.
(A) The joint distribution of the somatic activation as and the maximal dendritic input U* with different resistances. (B) The probability of detecting a dendritic spike remains constant even if the resistance changes 2–3 order of magnitude. Black circles: both somatic and dendritic resistances are altered; green diamonds: only resistance of the dendritic membrane () is changed while
; red squares: somatic membrane resistance (
) is changed,
. Although the distribution of the somatic activation scales with the resistance (see panel A and Eq. 7), the detection probability of a single dendritic event remains relatively constant. (C) The joint distribution of the activation of a dendritic branch
and its own input Ui. When the resistance is low (left), the local activation depends only slightly on the input. Conversely, if the resistance is higher (right) the local input has substantial impact on the activation of the branch. (D) The external influence decreases as the resistance increases. Symbols are the same as on panel B. Note, that decreasing the resistance of the perisomatic membrane (red squares) is the most efficient in separating the dendritic compartments (recall, that
). N = 30.