Thermodynamic Selection of Steric Zipper Patterns in the Amyloid Cross-β Spine
Figure 2
Ten possible β-sheet bilayer patterns of parallel β-sheets.
(A) GNNQQNY and (B) NNQQ. The filament axis is vertical, and top/bottom layers are represented by dark/light arrows, where each arrow represents a single peptide. Top left in (A): A side view of a single GNNQQNY peptide with even-/odd-numbered side chains in yellow/red, which defines Front/Back faces of the parallel β-sheet. Bottom right in (A): relaxation of BBA1 after MD (axial view; cf. Fig. 5).