Temporal Controls of the Asymmetric Cell Division Cycle in Caulobacter crescentus
Figure 2
All proteins (ovals) are assumed to be produced and degraded at specific rates. Only degradation of CtrA and CtrA∼P is depicted explicitly (4 small circles indicate products of degradation), in order to show how these steps are regulated. Solid lines correspond to the mass flow while dashed lines denote regulatory effects. P1 and P2 denote the two promoters controlling CtrA production. Purple lines signify the role of localization/delocalization effects in corresponding regulations. The double-stranded closed curve at the bottom left represents DNA. Cori is the origin of DNA replication and Ter stands for the termination site. DNA methylation sites on genes are marked by cyan stars. Z-ring closure at the far right blocks the flux of DivK and DivK∼P between swarmer and stalked cell compartments.