Model-Based Deconvolution of Cell Cycle Time-Series Data Reveals Gene Expression Details at High Resolution
Figure 8
A delay in ftsZ expression until the SW-to-ST transition is visible in the deconvolved profile.
Looking only at the population-level microarray expression data for ftsZ, there appears to be no delay in transcription from the time the experiment begins (left panel). However, it has been previously shown that transcription of ftsZ is repressed in SW cells and activated only when the DNA replication begins [20]. Repression of ftsZ expression in the SW phase is confirmed in the deconvolved expression profile (right panel). The gray bar indicates mean SW-to-ST transition phase +/− one standard deviation.