Building Disease-Specific Drug-Protein Connectivity Maps from Molecular Interaction Networks and PubMed Abstracts
Figure 6
An AD connectivity map linking AD-related proteins to significant drugs.
After ranking proteins involved in the AD related protein interaction network and selecting enriched drugs in AD network related corpus, 66 AD highly-relevant proteins and 166 significant AD candidate drugs are identified to construct an AD connectivity map. Hierarchical clustering of drugs and proteins are performed before results are shown as the final heatmap format, in which the x-dimension represents drugs and the y-dimension represents proteins. The color intensity for each cell is drawn in proportion to the connectivity score as shown in the heatmap legenda. Panels (A) and (B) show zoomed-in views of boxed regions A and B on the original map. Panel (C) shows the chemical structures of three drugs (Diazepam, Clonazepam, and Flunitrazepam) from a cluster of drugs found in Panel (B), with their common structure (Benzodiazepine) shown in a box. CID refers to entity identifier in PubChem (http://pubchem.ncbi.nlm.nih.gov/).