Building Disease-Specific Drug-Protein Connectivity Maps from Molecular Interaction Networks and PubMed Abstracts
Figure 4
Specificity and sensitivity tradeoffs for AD-related drug identification.
The ROC (receiver operating characteristic) curve shows the sensitivity vs. false positive rate (1-specificity) for AD-related drug identification, when FDR (false discovery rate) varies at different threshold levels. Evaluation results are built by querying against PubMed abstracts and Enrez gene function description in search of evidence that may contain any of the drug terms and the term “Alzheimer's Disease” with all their term variants. The sensitivity and specificity are defined in Methods section.