The Gene Ontology's Reference Genome Project: A Unified Framework for Functional Annotation across Species
Figure 3
The Gene Ontology's brower AmiGO displays Comparison Graph for genes presents in homolosets.
Those show all annotations, both experimental (evidence codes: IDA, IMP, IGI, IPI, IEP) as well as those inferred from sequence similarity to an experimentally characterized gene (ISS) and by curators (IC). Direct annotations to a GO term are indicated by colored wedges. Different species are represented by different colors. What species to display can be selected from the Control Panel on the righ hand side (here, the species selected are H. sapiens, D. reiro, and E. coli). The wedges also contain a small color-coded circle that indicates whether the annotation to a term is based on experimental data (green), supported by sequence similarity (blue), or is annotated with other evidence (no circle in the wedge). Mousing over a term leads to the display of the term ID, term name, and a complete list of annotations to that term by species. Here we show the term “chromosome segreagation”, for which five of the twelve species have experimental data to support that annotation. Annotations based on experimental data are indicated by “E”, and those based on sequence similarity by an “I”.