Global Prediction of Tissue-Specific Gene Expression and Context-Dependent Gene Networks in Caenorhabditis elegans
Figure 2
(A) Accuracy of predictions for major tissues. These precision-recall plots demonstrate the trade-off between the number of genes predicted and the fraction of the predictions that is correct. Red lines show the performance of our approach using all available microarray data, while green lines show performance using only whole-animal studies. High precision can be achieved by using whole-animal experiments alone. The accuracy and coverage of existing high-throughput studies is shown with triangles and circles. The use of datasets addressing tissue-specific expression improves accuracy in some but not all cases. (B) Precision at 10% recall for small tissues compared with expected precision based on the genomic background. We compare the fraction of true positives in the top 10% of our predictions against the fractions that would be expected if the genes were chosen randomly (genome background).