A Probabilistic Model of RNA Conformational Space
Figure 8
Selection of the best models using the Akaike Information Criterion.
The Akaike Information Criterion (AIC) scores are shown for all trained BARNACLE models (top) and mixture models (bottom). The AIC score reaches a minimum for the best model. The BARNACLE model with 20 hidden states, and the mixture model with 25 states have the best AIC scores (shown in red). The best models for each given number of hidden states are shown in black. The dotted lines are tendency lines constructed by cubic splines [43]. The three outliers in the BARNACLE plot (at 10 and 15 hidden states) illustrate that the stochastic expectation maximization procedure can get stuck in a local optimum. Note that the best BARNACLE model has a lower (better) score than the best mixture model.