FINDSITELHM: A Threading-Based Approach to Ligand Homology Modeling
Figure 2
The degree of sequence and structure conservation for the protein's ligand-binding region.
(A) Average sequence entropy, average normalized B-factor for (B) the Cα atoms and (C) the side chain heavy atoms as well as (D) a random property assigned to anchor and non-anchor CBRs. The populations of anchor and non-anchor CBRs were determined using different probability thresholds for anchor residues. Top plots show the p-value of the t-test applied to both populations of CBRs with respect to the property under consideration.