Structural Adaptation and Heterogeneity of Normal and Tumor Microvascular Networks
Figure 2
Summary of computational approach.
In-vivo experimental data on network structure (vessel diameter, length and connection pattern) were acquired during intravital microscopy (photomontage, left panel). Blood flow and oxygen distribution were calculated and diameter adaptation was simulated until a steady state was reached (computer visualization, right panel). Structural and functional parameters after simulated adaptation with different adaptation rules were compared with corresponding parameters for tumor and mesentery networks with measured diameters.