A Structure-Based Approach for Detection of Thiol Oxidoreductases and Their Catalytic Redox-Active Cysteine Residues
Figure 2
Amino acid composition of thiol oxidoreductases and control proteins.
An average composition at 6Å (A) and 8 Å (B) distances from Cys for proteins in the thiol oxidoreductase and control datasets, separated by function and fold as described in the text. Abbreviations: Trx fold OxR, thioredoxin-fold thiol oxidoreductases; Non Trx fold OxR, other thiol oxidoreductases; FAD OxR, FAD-containing thiol oxidoreductases and Non OxR, proteins in the control dataset (Table S2). Random Cys refers to a set of 1800 proteins randomly selected from PDB, mentioned in the text. The calculated standard deviations are also shown.