Prediction of Protein Binding Regions in Disordered Proteins
Figure 6
ANCHOR prediction for human p27.
Top: Number of atomic contacts (green) and prediction output (blue) and for the N-terminal binding region of human p27. “D1”and “D2” denote the two strongly interacting domains (red boxes) and “LH” denotes the weakly interacting linker domain between them (yellow box). Bottom: Crystal structure of human p27 (red and yellow) complexed with CDK2 (magenta) and Cyclin A (blue) (PDB ID: 1jsu [62]). Red parts denote regions that are predicted to bind by the predictor. These regions correspond to the experimentally verified strongly binding regions of p27. The figure was generated by PyMOL.