Allosteric Transitions of Supramolecular Systems Explored by Network Models: Application to Chaperonin GroEL
Figure 2
Schematic description of aANM method.
Two sets of intermediate conformations are generated, and
(1≤k≤ktot), starting from the known substates
and
, illustrated here for k = 1 and 2. The distance vector between the instantaneous endpoints at the kth step is denoted as
, and the deformation at each step is
or
. Dashed ellipses indicate isoenergetic contours.