A Dynamic Network Approach for the Study of Human Phenotypes
Figure 6
Directionality of disease progression.
A. Distribution of λ1→2 B. Disease precedence Λi as a function of disease prevalence Pi. The inset shows the same plot after removing the trend from disease precedence (Λi* = ΛI+496.08log10(Pi)-2446.2) C. Disease connectivity calculated from the φ-PDN as a function of Λi*. The green line shows the best fit for the 518 diseases with a prevalence larger than 1/500 (green circles) while the red line shows the best fit for the 463 diseases at the center of the cloud (red points). The correlation coefficient is represented by r and its associated p-value by p. D. Percentage of patients that died 2 and 8 years after being diagnosed with a disease with a given detrended precedence Λi*. The green lines show the best fit for all the 518 diseases (green circles) while the red lines show the fit for the 434 (top panel) and 465 (bottom panel) diseases at the bulk of the cloud.