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Inferring Stabilizing Mutations from Protein Phylogenies: Application to Influenza Hemagglutinin

Figure 9

Predicted stability effects of known temperature-sensitive and revertant mutations to H1 hemagglutinin.

In the plots at left, bars indicate the distribution of predicted values for all single mutations, while symbols show predicted values for the temperature-sensitive and revertant mutations. At right is the phylogenetic tree utilized by the PIPS program. The tree labels give the hemagglutinin subtypes and corresponding numbers of sequences. The PIPS predictions are made using the informative priors.

doi: https://doi.org/10.1371/journal.pcbi.1000349.g009