Inferring Stabilizing Mutations from Protein Phylogenies: Application to Influenza Hemagglutinin
Figure 5
Experimentally measured and predicted values for the 68-residue cold shock protein.
The plots at left show the predictions made by the CUPSAT physicochemical modeling program, the consensus approach, and the PIPS phylogenetic inference program using the informative, regularizing, and hydrophobicity priors. To the right is the phylogenetic tree of 763 sequences that was utilized by the PIPS program. The values are the squared Pearson correlation coefficients.