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Inferring Stabilizing Mutations from Protein Phylogenies: Application to Influenza Hemagglutinin

Figure 2

Stability distributions and fixation probabilities.

The panel at left show the probability that a protein in an evolving population will have extra stability , as given by Equation 3. The panel at right shows the probability that a mutation that causes a stability change of will be neutral, as given by Equation 4. The units for are arbitrary; for concreteness here we give them units of kcal/mol.

doi: https://doi.org/10.1371/journal.pcbi.1000349.g002